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DeFranco's Pregnenolone

  • $ 3895

What is pregnenolone?
Pregnenolone is an endogenous steroid hormone. It is synthesized within the body from cholesterol via an enzyme located in the mitochondria. Its production is controlled by hormones from the pituitary gland, like ACTH, FSH, & LH. Pregnenolone is biologically active on its own and also is a precursor of progesterone, mineralocorticoids (like aldosterone), glucocorticoids (like cortisol), androgens (like DHEA and testosterone), and estrogen. Because it is the precursor to all of these other hormones, it is sometimes known as the mother hormone.’ This hormone acts as a “neurosteroid.” It is found in high concentrations in certain areas of the brain and affects synaptic functions, is neuroprotective, and enhances myelinization. Cholesterol is the precursor to pregnenolone. Then, pregnenolone can convert to either progesterone or to 17-alpha-hydroxypregnenolone. Thereafter, it can be shunted to cortisol or down a different pathway to DHEA, then testosterone and estradiol (estrogen).

Here are some examples of what DeFranco's Pregnenolone is most commonly used for:

  • Cognitive enhancement / Mental clarity
  • Hormonal balance
  • Treatment of PTSD
  • Treatment of traumatic brain injury (shortly after the injury has occurred)
  • Insomnia (dosed in the morning)
  • Adrenal fatigue
  • Memory
  • Anxiety
  • Depressed mood
  • Treatment of allergies


*ATTENTION ATHLETES: Supplementing with Pregnenolone is banned by most high school, college & professional sporting organizations. Check with your specific school/organization before purchasing this product. 


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